摘要
食物营养成分在肠道中可被分解产生游离脂肪酸.游离脂肪酸除了被吸收氧化分解产生能量供机体利用外,还能通过结合脂肪酸受体激活信号通路,参与多种生理功能的调节,如维持能量平衡、代谢稳态、调节脂质形成与分解、影响机体免疫、结识流动消化成分间接监测菌群数量等.被确认的游离脂肪酸受体包括结合长链脂肪酸的G蛋白偶联受体(GPR)120,结合中链脂肪酸的GPR84,结合短链脂肪酸的GPR41及GPR43.对这些脂肪酸受体的研究可进一步了解肠道脂肪酸的消化与吸收、机体能量平衡与脂质代谢,对增强肠道营养、调节机体免疫和开发针对脂质代谢紊乱疾病的药物有着重要意义.
Dietary nutrients can be decomposed to gener-ate free fatty acids （FFA） in the intestine.Although the majority of FFA are absorbed and oxidized to produce energy for the organism,FFA are also involved in the regulation of many physiological functions,such as maintenance of energy balance,metabolic homeostasis,synthesis and decomposition of lipids,immunity,and intestinal ora regulation,through binding to FFA receptors and activating related signaling pathways.Several FFA receptors have been identified,including GPR41 and GPR120,activated by long-chain fatty acids,GPR84,activated by medium-chain fatty acid,GPR41 and GPR43,activated by short-chain fatty acids.Elucidation of mechanisms of action of these FFA receptors will help understand the digestion and absorption of fatty acids in the intestine,energy balance and lipid metabolism,which has great significance in enhancing nutrition,regulating immunity,and developing drugs for lipid metabolism disorders.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第8期820-826,共7页
World Chinese Journal of Digestology
基金
中国科学院青年人才领域前沿基金资助项目
No.ISACX-LYQY-QN-0701
湖南省自然科学基金资助项目
No.10JJ4013
广东省中国科学院全面战略合作基金资助项目
No.2010B090300038~~
关键词
游离脂肪酸
脂肪代谢
G蛋白偶联受体
Free fatty acid
Fat metabolism
G protein-coupled receptors
