摘要
背景与目的已有的研究表明:工作环境烟草暴露与非吸烟人群肺癌发生有密切关系并不十分明确,本研究旨在探讨工作环境烟草暴露与非吸烟人群肺癌发生危险的关系。方法通过计算机检索Medline(1954年-2010年8月)、CENT L(the Cochrane central register of controlledtrials)(2010issue3)、EMBASE(1970年-2010年8月)中国生物医学文献数据库系统(CBM)(1978年-2010年8月)、中国期刊全文数据库(CNKI)(1979年-2010年8月)、中文科技期刊全文数据库(VIP)(1989年-2010年8月)等数据库,收集国内外公开发表的关于工作环境烟草暴露与非吸烟人群肺癌发生关系的研究文献,应用统计软件Stata11.0进行数据分析,计算其合并优势比(oddsratio,OR)和95%置信区间(con dence interval,CI)。采用Begg法对发表偏倚进行量化检测。结果最终纳入分析的文章共有22篇,合并分析结果表明工作环境烟草暴露使非吸烟人群肺癌发生率增加了25%(OR=1.25,95%CI:1.13-1.39,P<0.001),使非吸烟女性肺癌的发生率增加了22%(OR=1.22,95%CI:1.05-1.42,P=0.011);工作环境烟草暴露导致非吸烟男性肺癌的发生率增加了54%,但无统计学意义(OR=1.54,95%CI:0.74-3.18,P=0.247)。结论工作环境烟草暴露是非吸烟人群肺癌发生的一个危险因素,非吸烟女性工作环境的烟草暴露与肺癌的发生关系密切。
Background and objective It has been reported that there was a close relationship between lung cancer risk and environmental tobacco smoke at workplace. The aim of this study is to explore the relationship between workplace environmental tobacco smoke exposure and lung cancer risk among non-smoking subjects. Methods By searching Medline,CENTRAL（the Cochrane central register of controlledtrials） ,EMBASE,CBM,CNKI and VIP et al,we collected both domes-tic and overseas published documents on workplace environmental tobacco smoke exposure and lung cancer risk. Random or fixed effect models were applied to conduct systematic review on the study results,the combined odds ratio（OR） and the 95% confidence interval（CI） were calculated as well. Results 22 reports were included into the combined analysis,which indicated that 25% lung cancer risk was increased by exposing to workplace environment tobacco smoke（OR=1.25,95%CI： 1.13-1.39,P0.001） . For female the increased risk was 22%（OR=1.22,95%CI： 1.05-1.42,P=0.011） . For male the increased risk was 54%,but it does not reach the statistical significance（OR=1.54,95%CI： 0.74-3.18,P=0.247） . Conclusion Workplace environmental tobacco smoke exposure is an important risk factor of lung cancer risk among non-smoking subjects. Especially for non-smoking women who expose to workplace environment tobacco smoke have a close relationship with lung cancer.
出处
《中国肺癌杂志》
CAS
2011年第4期345-350,共6页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
环境
烟草
系统评价
Lung neoplasms
Environment
Tobacco
Systematic review
