摘要
目的：研究TGF－β与动脉粥样硬化形成的关系。方法：用10％胆固醇脂肪乳剂复制大鼠和家兔的高脂血症模型，免疫组织化学和ELIA等技术检测其动脉和周围血的TGF－β1、β2、β3及其受体，观察比较两种动物动脉粥样硬化形成的情况和血清中的脂蛋白及总胆固醇水平。结果：实验组家兔100％形成动脉粥样斑，血清高密度脂蛋白在正常范围；实验组大鼠未见动脉粥样斑形成，但其血TGF－β和高密度脂蛋白随实验时间（鼠龄）的延长而升高。结论：ITGF－β可能在动脉内膜被高脂血症损伤后的炎性增生反应过程中起作用。
To study the effect of transfouming growth factor - β(TGF - β) to atherosclerosis (AS). METH-0DS:Hyperlipoidemic model in SD-rats and rabbits were madel in SD-rats and rabbits with lO% cholesterol - containing lipid emul-sion. TGF - β expression and its receptor in arteries and TGF - β serum level of these anilnals tvere detected by driunohisto-chdrical and ELLSA tecboqes. AS and serum level of lipoproteins and total cholesterol were compared between rats and rab-bits. RESULTS:10% of the experimental Iabbits resulted in AS with noImal high density lipoProtein(HDL) serurn level.Serm leVeIs of TGF - β and HDL of Iats were incrend with prolonging of the opdriental thae but without developing 0fthe AS - C0NCLUSI: wr - β may be effective only in mechve proliferation after arterial inhma was injured by hyPer-lipoidemia. AS is a chronic inflaxnmatory proliferative disease induced by abnormal lipometabolism.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第10期894-897,共4页
Chinese Journal of Pathophysiology
