摘要
目的评价左氧氟沙星联合阿奇霉素治疗高龄人群难治性呼吸道感染的疗效与安全性。方法对68例难治性细菌性呼吸道感染的高龄患者随机分为治疗组和对照组,治疗组34例给予左氧氟沙星联合阿奇霉素治疗;对照组34例给予左氧氟沙星治疗,两组总疗程皆为15 d。结果治疗组与对照组的有效率分别为64.71%和32.35%,呼吸道细菌清除率分别为76.19%和36.36%,差异均有统计学意义(P<0.05)。两组不良反应发生率皆低。结论左氧氟沙星联合阿奇霉素治疗高龄人群难治性呼吸道感染临床疗效优于单用可乐必妥,疗效确切而且安全。
Objective To evaluate the efficacy and safety of levofloxacin combined with azithromycin in the treatment of refractory respiratory tract infection in senile patients.Methods 68 patients with refractory bacterial respiratory infections were randomly divided into treatment group（n=34）and control group（n=34）.Patients in treatment group were given levofloxacin combined with azithromycin and those in control group were only given levofloxacin.The course of treatment was 15 d in both groups.Results The effective rate in treatment and control groups was 64.71% and 32.35%,respectively.The clearance rate of respiratory tract bacteria was 76.19% and 36.36%,respectively.The differences were all significant（P0.05）.Both groups had low incidence of adverse reaction.Conclusion Levofloxacin combined with azithromycin is safe to treat refractory respiratory tract infection in senile patients.Its clinical efficacy is better than that of single levofloxacin treatment.
出处
《西南国防医药》
CAS
2011年第5期497-499,共3页
Medical Journal of National Defending Forces in Southwest China
