摘要
目的 探讨运动诱发电位(MEP)对脊髓缺血再灌注损伤中神经功能的监测作用。 方法 对26 只大鼠腰骶段脊髓缺血前、缺血15、25 、40 分钟及再灌注后5、15、30 分钟、1、2 和24 小时MEP变化进行监测。 结果 在缺血15 分钟时MEP潜伏期明显延长(P< 0.01) ,波幅在缺血25 分钟时明显减小( P< 0-01) ,缺血40 分钟时波形消失;再灌注后5 分钟时波形恢复,但潜伏期大于正常(P<0-01) ,波幅小于正常(P<0-01);再灌注后15 分钟至2 小时波幅恢复正常(P> 0-05),潜伏期无恢复;再灌注后24 小时潜伏期虽然呈恢复趋势,但与再灌注早期相比,差异无显著性意义,此时波幅又明显下降低于正常(P<0-01) ,再灌注后24 小时双下肢运动功能比再灌注早明显降低( P< 0-05) 。
Objective To investigate the method monitoring the neurologic function of spinal cord ischemia and reperfusion injury. Methods Motor evoked potentials(MEP)were monitored at different time points during ischemia and reperfusion of the lumbar spinal cord of the rat. Results MEP latency increased 15 minutes after ischemia( P <0 01) and MEP amplitude decreased 25 minutes after ischemia ( P <0 01). MEP disappeared 40 minutes after ischemia and reappeared 5 minutes after reperfusion,but the latency was still longer and the amplitude was lower than the normal value ( P <0 01). The amplitude returned to normal 2 hours after reperfusion( P >0 05) in contraste to the latency. 24 hours after reperfusion, the amplitude decreased again, and motor funtion of rat hind limbs was more decreased than that at early time of reperfusion( P <0.05). Conclusion MEP is a sensitive index for spinal cord ischemia and reperfusion injury.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1999年第10期617-619,共3页
Chinese Journal of Surgery