摘要
目的探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者合并贫血的临床意义。方法选取AECOPD住院患者病例99例，记录患者性别、年龄、住院时间、血常规、C反应蛋白（CRP）、血清白蛋白、动脉血气、肺功能、身高、体质量、严重程度分级、呼吸机使用情况等临床指标。以COPD患者是否贫血分为两组，回顾性分析红细胞参数、FEV1占预计值％、体质量指数（BMI）、血清白蛋白、住院时间等参数组间差异，分析血红蛋白水平与各临床参数间相关性。结果①AECOPD合并贫血主要表现为轻中度贫血，贫血组各项红细胞参数除红细胞体积外均较非贫血组低；②血红蛋白水平与住院天数、CRP、FEV。占预计值％呈负相关，与血清白蛋白呈正相关，而与年龄、转归、吸烟情况、咳喘年数、氧合指数、BMI、COPD严重程度分级不相关；③贫血组住院天数较非贫血组明显延长，血清白蛋白较低，CRP较高，而贫血组年龄、BMI、FEV1％、氧合指数与非贫血组比较，差异无统计学意义。结论贫血组住院时间长、炎症反应重、蛋白消耗较大，需加强抗炎治疗、营养支持治疗，以利于病情恢复。
Objective To analysis the clinical significance of chronic obstructive pulmonary disease with acute exacerbation （AECOPD）patients with anemia. Methods Selecte 99 cases of patients hospitalized patients with AECOPD, record gender, age, length of hospital stay, CRP, albumin, arterial blood gases, lung function, height, weight, severity classification, the use of ventilator and other clinical parameters. Retrospective analysis of RBC parameters, FEV1 percentage of predicted value, body mass index, serum albumin, length of stay and other parameters between anemia and no-anemia groups, analysis the correlation of Hb levels with various clinical parameters. Results （1） AECOPD complicated anemia mainly for mild to moderate anemia, RBC parameters of the anemia group were lower than nonanemic except MCV. （2）Hb level were negative correlated with length of hospital stay, CRP, and FEV1 pred,were positive correlated with albumin. （3） Anemia group hospital stay was significantly longer than non-anemic, lower blood albumin, higher CRP. Conclusions Anemia group has long hospital stay, serious inflammatory response, greater protein consumption, need to strengthen anti-inflammatory therapy, nutritional support, facilitate disease recovery.
出处
《国际呼吸杂志》
2011年第9期668-671,共4页
International Journal of Respiration
关键词
慢性阻塞性肺疾病急性加重期
红细胞参数
贫血
Chronic obstructive pulmonary disease with acute exacerbation
Erythrocytes parameters
Anemia
