摘要
目的:探讨BRCA2和P53蛋白表达在散发性乳腺癌中的作用。方法:收集86例乳腺癌及癌旁组织、48例乳腺增生症手术标本,采用免疫组化S-P法检测BRCA2及P53蛋白在各例中的表达情况。结果:①BRCA2表达在乳腺癌、乳腺癌旁组织、乳腺增生症中的阳性率分别为41.8%(36/86)、75.6%(65/86)和97.9%(46/48)三组间比较,差异有统计学意义(P<0.01);②p53在乳腺癌、乳腺癌旁组织、乳腺增生症中的阳性率分别为37.2%(32/86)、16.3%(14/86)和8.3%(4/48),三组间比较,差异有统计学意义;③乳腺癌组织中BRCA2与p53表达之间差异,无统计学意义(r=0.612,P>0.05)。结论:BRCA2和p53蛋白异常表达在散发性乳腺癌发生发展过程中起着一定作用。
Objective：To investigate the role of expreession of BRCA2 and P53 protein in sporadic brease cancer.Methods：86 cases of breast caner and adjacent cancer tissuse,and 48 cases of surgical specimens of breast hyperplasia were proved by clinical phthology,The expression of BRCA2 and P53 proteina wad determinde by SP immunohistochemistry.Results：①The positive expression artes of BRCA2 in breast cancer,adjacent cancer tissuse and breast hyperplasia wer 41.8%（36/58）,75.6%（65/86） and 97.9%（46/48） respectively.Among the three groups,the difference was statistically significant（P0.01）.②The positive expression rates of P53 in breast cancer,adjacent cancer tissues and breast hyperplasia were 37.2%（32/86）,16.3%（14/86）and 8.3%（4/48）respectively.Among the three groups.the difference was statistically significant.③There is no significant correlation betwenn levels of BRCA2 and P53 in breast cancer tissues（r=0.612,P0.05）.Conclusion：The abnormal expression of BRCA2 and P53 protein plays and important role in the occurrence and development of the breast cancer..
出处
《内蒙古医学杂志》
2011年第3期260-264,共5页
Inner Mongolia Medical Journal
