摘要
目的探讨联合检测甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类抗原19-9（CA19—9）辅助诊断消化系统恶性肿瘤的临床应用价值。方法对821例消化系统恶性肿瘤患者采用化学发光法检测血清AFP、CEA、CA19-9水平。结果恶性肿瘤组和良性肿瘤组AFP、CEA、CA19—9水平均明显高于健康对照组（t=2．345、2．224，均P〈0．05；t=2．785、2．749、2．897、2．865，均P〈0．01）；恶性肿瘤组AFP、CEA、CAl9-9水平均明显高于良性肿瘤组（t=2．445，P〈0．05；t=2．745、2．819，均P〈0．01）；肝癌患者AFP水平明显高于其它癌症（t=2．715、2．812、2．877、2．845、2．799，均P〈0．01）；肝癌患者CEA水平明显低于结、直肠癌和胰腺癌（t=2，775、2．801，均P〈0．01）；胰腺癌、胆道恶性肿瘤CA19—9水平明显高于其它癌症（t=2．733、2．851、2．788，均P〈0．01）；肝癌、胃癌、结直肠癌、胰腺癌、胆道恶性肿瘤3项联合检测阳性率分别为91．0％、90．0％、88．0％、90．0％、70．2％均高于单项检查阳性率85．0％、72．0％、67．5％、79．4％、55．3％（x^2=3．781、3．841、3．798、3．814、3．994，均P〈0．05）。结论三项肿瘤标记物均可作为消化系统恶性肿瘤的辅助诊断指标，联合检测可提高消化系统恶性肿瘤的检出率。
Objective To investigate the clinical value of combined tests ,including A-fetus protein （AFP）, cancer embryo agent （CEA） , earbonhydrate agent 19-9 （CA19-9）for the diagnosis of malignant tumors in digestive system. Methods ChemicaliU-umination tests were used to detect serum levels of AFP,CEA and CA 19-9 in 821 pa- tients with diseases of digestive system. Results The levels of AFP, CEA, CA19-9 in malignant group and the benign group were significandy higher than the control group （ t = 2. 345,2. 224, all P 〈 0.05 ; t = 2. 785,2. 749,2. 897, 2. 865, all P 〈0.01） ;The levels of AFP,CEA,CA19-9 in malignant group were signifieandy higher than benign group （ t = 2. 445, P 〈 0.05 ; t = 2. 745,2.819, all P 〈 0.01 ） ; The level of AFP in liver cancer group was significantly higher than other groups （ t = 2.715,2.812,2. 877,2. 845,2. 799, all P 〈 0.01 ） ; The level of CEA in liver cancer group was significantly lower in patients with liver colorectal cancer and pancreatic cancer （ t = 2. 775,2.801, all P 〈 0.01 ） ; The level of CA19-9 in bile duct cancer group was significantly higher than that of other cancers （ t = 2. 733,2.851,2. 788, all P 〈 0.01 ） ; The positive rates of liver,stomach ,colorectal cancer,pancreatic cancer,bile duct cancer combined detection in three item were 91.0% ,90.0,88.0% ,90.0% ,70.2% which were higher than the single check-positive rate of 85.0% ,72.0% ,67.5 % ,79.4% ,55.3 % （ X2 = 3.781,3.841,3. 798,3.814,3. 994, all P 〉 0.05）. Conelttsion The three tumor markers could be used as attxiliary diagnostic and joint detection which could improve the detection rate in patients with malignant tumors of digestive system.
出处
《中国基层医药》
CAS
2011年第7期913-915,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肿瘤标记
生物学
环境检测
消化系统肿瘤
Tumor markers,Biological
Environmental Monitoring
Digestive System Neoplasms
