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超前镇痛对大鼠脊髓损伤后炎性介质的影响

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摘要 目的研究凯芬和加罗宁超前镇痛对大鼠脊髓损伤后炎性介质的影响。方法 48只大鼠随机分成凯芬和加罗宁组,超前镇痛前和脊髓损伤模型建立后6h采血测定血清IL-8、IL-6、NO和NOS值。结果加罗宁组和凯芬组相比,NO、NOS均明显降低(P<0.01),而IL-8、IL-6值均显著升高(P<0.01)。结论脊髓急性损伤早期,超前镇痛常用剂量凯芬比加罗宁能显著抑制脊髓损伤后炎性介质水平。
作者 刘长续
出处 《中国实用医药》 2011年第11期119-120,共2页 China Practical Medicine
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