摘要
目的探讨希罗达联合奥沙利铂治疗晚期贲门癌的近期疗效及毒副反应。方法 45例患者均采用联合化疗方案,希罗达1000mg/(m2·d),分早晚2次,连服2周。奥沙利铂130mg/m2第1天静脉滴注,21d为1个周期,每个患者至少2周期的化疗。结果完全缓解(CR)2例,部分缓解(PR)24例,稳定(SD)12例,进展(PD)9例。有效率(CR+PR)57.8%。本组主要毒副反应为消化道反应,恶心、呕吐及腹泻;血液学毒性表现为白细胞减少、血小板减少及贫血;手足综合征也常见,另外还有感觉异常、疲劳等。结论希罗达联合奥沙利铂治疗晚期贲门癌疗效确切,毒副反应可以耐受。
Objective To evaluate the clinical effects and toxicities in treating late gastric cardia carcinoma using Capecitabine（Xeloda） combining oxaliplatim.Methods Xeloda 1000 mg/m^2 /day in dividing two dose per oral continued for two weeks,Oxaliplatin 130 mg/m^2 intravenously injected by drip in the first day within 21 days,with at least 2 cycles.Results Complete regression 2 case,partial regression 24 cases,stability 12 cases,and disease progression 9 cases.The overall efficient rate was 57.8%.The main toxic effects were gastrointestinal tract reations,myelosupression,hand and foot syndrome and neuro-sensory toxicity etc.Conclusion Combination chemotherapy with Xeloda-Oxaliplatin is certainly effective and tolerable to toxicities in the treatment of advanced gastric cardia carcinoma
出处
《中国实用医药》
2011年第11期30-32,共3页
China Practical Medicine
关键词
希罗达
奥沙利铂
联合化疗
贲门癌
Xeloda
Oxaliplatin
Combination chemotherapy
Gastric cardia carcinoma
