摘要
[目的]探讨多药耐药基因相关蛋白在胃癌组织中的表达及其与预后的关系。[方法]免疫组化方法检测109例胃癌组织中ToPoⅡ、MRP、GST-π的表达,并分析他们与胃癌临床病理特征和预后间的关系。[结果]109例胃癌组织中,ToPoⅡ、MRP、GST-π阳性率分别为74.3%、40.4%和48.6%。3种蛋白各自表达的阳性组与阴性组比较,1、3、5年生存率均无统计学差异。高危组(2个以上危险因素)1、3、5年生存率分别为85.1%、57.4%、46.8%;低危组(1个危险因素)1、3、5年生存率分别为85.5%、64.5%、61.3%,但差异无统计学意义(χ2=0.15,P=0.926)。[结论]ToPoⅡ、MRP、GST-π与胃癌临床病理特征相关,3种耐药蛋白的联合检测可能成为预测胃癌患者预后的指标。
[Purpose] To investigate the expression of multidrug resistance （MDR） gene related proteins in gastric carcinoma and its relationship with prognosis.[Methods] The expression of ToPoisomeraseⅡ（ToPoⅡ）,multidrug resistance protein（MRP）,glutathione S-transferase π（GST-π） in 109 patients with gastric carcinoma was detected by immunohistochemistry.The relationship of ToPoⅡ,MRP,GST-π expressions with prognosis was analyzed.[Results] Of 109 cases with gastric carcinoma,the positive expression rate of ToPoⅡ,MRP,GST-π was 74.3%,40.4% and 48.6% respectively.The 1-,3-,5-year survival wasn’t significant different between each protein positive expression and negative expression.The 1-,3-,5-year survival in high risk group （≥2 risk factor） was 85.1%,57.4%,46.8% respectively,and 85.5%,64.5%,61.3% in low high risk group （1 risk factor）,with no significant difference（χ2=0.15,P=0.926）.[ Conclusion] ToPoⅡ,MRP,GST-π is related to the pathological features of gastric carcinoma.Combination detection of 3 kinds of MDR related proteins might become a marker for predicting prognosis in patients with gastric carcinoma.
出处
《肿瘤学杂志》
CAS
2011年第4期249-252,共4页
Journal of Chinese Oncology
关键词
多药耐药基因相关蛋白
胃肿瘤
预后
multidrug resistance gene related protein
gastric neoplasms
prognosis
