摘要
目的探讨血清胱抑素C(SCy-C)联合尿微量清蛋白(mALB)检测在糖尿病肾病早期诊断中的价值。方法将研究对象分为糖尿病肾病组50例及健康体检正常者(阴性对照组)50例。两组均取晨尿,采用免疫透射比浊法检测mALB;乳胶增强散射免疫比浊法检测SCy-C;酶法检测血清肌酐(Scr)和尿素氮(BUN)。结果各指标对肾功能早期病变的检出百分率总体为SCy-C+mALB>SCy-C>mALB>Scr>BUN。糖尿病肾病组患者mALB和SCy-C水平均显著高于阴性对照组,差异有统计学意义(P<0.01)。结论 mALB和SCy-C联合检测可提高糖尿病早期肾功能损害检出率。
Objective To investigate the importance of cystatin C combined with urine microalbumin testing in diagnosing early-stage diabetic nephropathy.Methods The 50 samples of patients with diabetic nephropathy were taken as the diabetic nephropathy group and 50 diabetic nephropathy negative patients were taken as control group.Urina sanguinis was taken from both groups,and urinary albumin（mALB） was tested by immune turbidimetric assay method.Serum cystatin C（SCy-C） was tested by immune latex enhanced turbidimetric assay scattering method.Serum creatinine（Scr） and urea nitrogen（BUN） were tested by enzymatic method.Results The successful recognization rate of early-stage lesions by these indexes of renal function are as followed： SCy-C＋mALB 〉SCy-C〉 mALB〉Scr BUN.The mALB and SCy-C levels in diabetic patients were significantly higher than those in the control group（P〈0.01）.Conclusion mALB combined with SCy-C detection of diabetes can increase the recognization rate of early renal lesion.
出处
《检验医学与临床》
CAS
2011年第9期1057-1058,共2页
Laboratory Medicine and Clinic
