摘要
目的:系统评价国内大柴胡汤及其加减方治疗急性胰腺炎临床随机对照试验。方法:采用Cochrane循证医学系统评价方法,检索CNKI、维普、万方期刊全文数据库。采集大柴胡汤及其加减治疗急性胰腺炎的临床随机对照试验中的相关数据,在严格质量评价的基础上,利用RevMan4.2进行Meta分析疗效及异质性检验;用倒漏斗图分析发表性偏倚。结果:共有6篇随机对照试验519个病例满足纳入标准。所有试验普遍质量不高,未发现双盲及分配隐藏。大柴胡汤及其加减治疗(总有效率)的效应值(治疗组与对照组疗效的比)OR=3.60,95%,可信区间[1.77,7.33];未有不良反应的描述;漏斗图提示存在发表性偏倚。结论:大柴胡汤及其加减治疗急性胰腺炎相对单纯西医常规治疗有一定疗效,但无有力的循证医学证据支持,应进行严格的、多中心的随机双盲对照试验,以提供更具说服力的证据。
Objective：To systematically evaluate the clinical randomized controlled trials about treating acute pancreatitis with modified DaChaiHuTang.Methods：applied cochrane reviewing approach in evidence-based medicine systematic,retrievaled CNKI,VIP,ESEARCH full database.collected related data in randomized controlled trial about treating acute pancreatitis with modified DaChaiHuTang,based on strict quality evaluation,doing Meta-analysis of efficacy and the heterogeneity test using RevMan4.2;analyzed publication bias with a funnel plot.Results：Total of six randomized controlled trials of 519 patients met the inclusion criteria.ll tests generally had low quality,double-blind and allocation concealment was not found.the effect value（the ratio of treatment group to the control group） of treating with modified DaChaiHuTang（total efficiency） OR = 3.60,95% CI was [1.77,7.33];no description of adverse reactions;funnel plot Indicated the presence of publication bias.Conclusion：Compared with treating with relatively simple routine western medicine,treating acute pancreatitis with modified DaChaiHuTang had a certain effect,but there was no strong evidence-based medicine to support,we should do more rigorous,multi-center randomized double-blind controlled trials to provide more convincing evidence.
出处
《甘肃中医》
2011年第5期15-17,共3页
Gansu Journal of Traditional Chinese Medicine
