摘要
目的检测复发性生殖器疱疹患者治疗前、后外周血T淋巴细胞亚群，观察治疗效果，并探讨机体细胞免疫的相关作用机理。方法复发性生殖器疱疹患者口服泛昔洛韦250mg，每天3次，连服5天，同时给予胸腺五肽1mg肌注，每天1次，15次为一疗程，共4个疗程。采用流式细胞仪检测52例复发性生殖器疱疹患者治疗前、后T淋巴细胞亚群（CD3^＋、CD4^＋、CD8^＋、CD4^＋/CD8^＋），并与40例健康对照组进行比较。结果治疗组与健康对照组相比外周血CD3^＋、CD4^＋及CD4^＋／CD8^＋下降，CD8^＋升高，两组间差异有统计学意义（P〈0．01）。经抗病毒药物与免疫调节剂联合治疗2个月后，外周血CD3^＋、CD4^＋及CD4^＋／CD8^＋回升，而CD8^＋下降，治疗前、后差异有统计学意义（P〈0．01）。治疗前每例年平均发作4．5次，治疗后每例年平均发作1．5次，治疗前、后差异有统计学意义（P〈0．05）。结论复发性生殖器疱疹患者存在细胞免疫功能紊乱，抗病毒药物与免疫调节剂联合应用能改善患者的细胞免疫功能紊乱状况，降低生殖器疱疹复发率。
Objective To observe the therapy efficacy in patients with recurrent genital herpes （ RGH ）via the detection of the change in peripheral blood T-lymphocyte snbpopulation, and to explore the related mechanisms of cell-mediated immunity. Methods 52 patients received a 4-course therapy with oral famciclovir of 250 mg, thrice daily for 5 days and an injection of thymopentin of 1 mg once daily for 15 days. T-lymphocyte subpopulation （ CD3^＋. CD4^＋, CD8^＋, and CD4^＋/CD8^＋ ）was detected by flow cytometry before and after treament. The results were then compared those from the healthy controls. Results As compared with thosse the control group, CD3^＋, CD4^＋. and CD4^＋/CD8^＋were decreased and CDg＋was in- creased in the treatment group, with a statistical difference Between the two groups （ P〈 0.01 ）. After a 2- month therapy with antiviral drugs and immunomodulators, CD3^＋, CD4^＋ and CD4VCD8^＋ elevated and CDs＋ declined. There was a statistical difference after treatment （ P〈 0.01 ）. Before treatment, each patient had flare-up 4.5 times annually on average, but only 1.5 times after treatment, with a statistical difference （ P 〈 0.05 ）. Conclusions Cellular immune dysfunction may occur in patients with RGH. Therapy with antiviral drugs and immunomodulators can in]prove cell-mediated immunity in the patients, and reduce the recurrence of genital herpes.
出处
《国际医药卫生导报》
2011年第9期1050-1053,共4页
International Medicine and Health Guidance News
关键词
复发性生殖器疱疹
细胞免疫
治疗
Recurrent genital herpes
Cell-mediated immunity
Treatment
