摘要
目的了解2型糖尿病患者糖化血红蛋白（HbAIc）达标对血脂的影响，探讨糖脂代谢的关联性。方法完全随机抽取上海市殷行社区95例2型糖尿病患者的糖化血红蛋白、血脂，按HbAlc≤6．5％和HbA1C〉7．0％分成2组，其中HbAlc达标组34例，HbAlc未达标组45例，比较2组的血脂情况，同时进行HbAlc与血脂的相关性分析。结果未达标组患者TC，TG，HDL-C，LDL-C明显高于达标组[分别为（5．42±1．04）mmol／L比（5．06±1．07）mmol／L、（2．90±1．59）mmol／L比（2．03±1．48）mmoVL、（1．09±0．14）mmoVL比（1．05±0．17）mmol／L、（3．16±0．58）mmol／L比（2．92±0．62）mmol／L]，且TG升高有统计学意义（P〈0．05），达标组TC，TG，LDH—C达标率明显高于未达标组[分别为5例（14．7％）比3例（6．7％）、17例（50．0％）比10例（22．2％）、6例（17．6％）比3例（6．7％），P〈0．05]。单因素分析结果表明HbAlc与TC、TG、LDH．C呈正相关（r=0．208、0．438、0．222，均P〈0．05）。结论降低HbAlc可有效降低TC、TG、LDL-C，同时HbAlc达标可以明显提高TG的达标率，2型糖尿病患者应定期监测HbAlc，控制HbAlc在正常水平。
Objective To understand the influence of lipid by up to standard type 2 diabet glycated hemo- globin and to discuss the relationship of saccharide metabolism and lipid metabolism. Methods Ninty-five patients with type 2 diabetes in Shanghai Yin-line Community were divided into two groups（ HbAlc ≤ 6.5 and HbAlc 〉 7.0）, the level of blood lipid in the two groups were compared. Meanwhile, 95 patients in the glycosylated hemoglobin and the corresponding blood were analyzed. Results TC, TG, HDL-C, LDL-C of substandard group [ （ 5.42± 1.04） mmol/L vs （ 5.06 ± 1.07 ） mmol/L, （ 2.90 ±1.59 ） mmol/L vs （ 2.03 ±1.48 ） mmol/L, （ 1.09 ± 0.14） mmol/L vs（ 1.05 ± 0.17 ） mmol/L, （3.16 ± 0.58 ） mmol/L vs（2.92 ± 0.62） mmol/L, respectively] were higher than those in standard group. TG of substandard group was significantly elevated （ P 〈 0.05 ）. The standard rate of TC, TG, HDL-C in standard group were higher than those in substandard group [5 cases（ 14.7% ） vs 3 ca- ses （ 6.4 % ）, 17 eases （ 50.0% ） vs 10 eases （22.2 % ）, 6 eases （ 17.6% ） vs 3 eases （6.7 % ）, P 〈 0.05 ]. Univari- ate analysis showed that HbAle and TC, TG, LDH-C was positively correlated （ r = 0. 208 ,0. 438 ,0. 222 , both P 〈 0.05）. Conclusions HbAlc reduction can effectively reduce TC, TG, LDL-C, while the standard of HbAlc can significantly improve the standard rate of TG. Type 2 diabetes should have regular monitoring of glycated hemoglobin and HbA1 c should be controlled at normal levels.
出处
《中国医药》
2011年第5期539-540,共2页
China Medicine
