摘要
中药克乳痛小鼠经口LD50未能测出，小鼠经口给药的最大耐受量为126g／kg，为临床成人1日口服量等效剂量的127倍。大鼠2个月的长期毒性试验表明，克乳痛对大鼠的生长发育，血液各细胞，肝肾功能，蛋白质脂肪和糖代谢，以及各实质器官无不良影响，未见迟缓性毒性。病理学检查各主要脏器组织学结构正常，未见病理性改变。
The Chinese herbs kerutong can't be mesured for LD50 in mice. The MTD in mice is 126g/kg-1, it equals 127 times of the equivalent dose to 1 day dose of an adult. The results of chronic toxicity assay for 2 months in rats showed that growth, hematic cells, functions of the liver and the kidney, metabolisms of the protein, the fat and the carbohydrate, main organs in 3 groups of rats were not affected. The delayed toxicity was not observed. The normal histomorphology of the main organs in 3 groups of rats were observed, the pathological changes were not examined.
出处
《现代预防医学》
CAS
1999年第3期306-307,共2页
Modern Preventive Medicine
