摘要
目的:探讨初发精神分裂症患者血清β2-微球蛋白水平变化及临床意义。方法:采用免疫比浊法对40例正常人(对照组)及50例初发精神分裂症患者(病例组)进行血清β2-微球蛋白水平测定;采用Pearson等级相关分析判断病例组血清β2-微球蛋白水平和临床资料之间的相关性。结果:病例组血清β2-微球蛋白含量明显高于对照组,差异有统计学意义(P<0.01);血清β2-微球蛋白含量与PANSS评分呈明显正相关(r=0.405,P<0.05)。结论:血清β2-微球蛋白水平升高对精神分裂症发生和发展可能有重要意义。
Objective:To investigate the expression and clinical significance of serum β2-microglobulin in initial schizophrenia.Method:The content of the serum β2-microglobulin in 40 healthy control and 50 patients with schizophrenia were measured by immunonephelometry analysis.The relations between serum β2-microglobulin and clinical data was detected using pearson correlation assay.Results:The content of serum β2-microglobulin in patitents with schizophraia was higher than that in the control with the significant difference(P<0.01).The serum content of β2-microglobulin was significantly positive related with PANSS score(P<0.05).Conclusion:The serum β2-microglobulin abnormalities might have a potential association with the pathogenesis of schizophrenia.
出处
《微循环学杂志》
2011年第2期42-43,I0002,共3页
Chinese Journal of Microcirculation
