摘要
目的 :探讨卡前列甲酯栓预防和治疗产后出血的疗效。方法 :对 40 0例正常足月妊娠阴道分娩者 ,随机分为卡前列甲酯栓组 30 0例和缩宫素组10 0例。卡前列甲酯栓组在胎儿娩出后向阴道内置入卡前列甲酯栓 1mg ;缩宫素组在胎儿前肩娩出后静脉注射缩宫素 10IU。结果 :产后 2h平均出血量卡前列甲酯栓组为 138mL±s 2 6mL ,缩宫素组为 2 85mL± 60mL (P <0 .0 1)。产后出血发生率卡前列甲酯栓组为 4.0 % ,缩宫素组为 30 % (P <0 .0 1)。卡前列甲酯栓组不良反应轻微。结论 :卡前列甲酯栓预防和治疗产后出血是安全和有效的药物。
AIM: To observe carboprost vs oxytocin for the pervention and treatment of postpartum hemorrhage. METHODS: Four hundred normal parturients were randomized into carboprost group (n=300) and the oxytocin group (n=100). The carboprost methylate suppository was put into vagina in carboprost group. The oxytocin group was given 10 IU oxytocin immediately after the delivery of anterrior shoulder of the fetus. RESULTS: (1)the amount of hemorrhage in 2 h postpartum was 138 mL±s 26 mL and 285 mL±60 mL. The difference between the 2 groups was statistically significent (P<0.01). (2) The postpartum hemorrhage rate in carboprost group was 4.0% and that in oxytocin group was 30%. It was statistically significant (P<0.01). (3) The adverse reactions were mild in carboprost group. CONCLUSION: Carboprost in prevention and treatment of postpatum hemorrhage is a safe and effective drug.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第5期303-305,共3页
Chinese Journal of New Drugs and Clinical Remedies
