摘要
目的：观察习惯性流产患者接受主动免疫治疗后免疫反应性的变化。方法：采用改良的体外混合淋巴细胞培养（ＭＬＣ） 模拟临床主动免疫治疗，刺激后的患者淋巴细胞的反应能力用ＣｏｎＡ 检测。结果：经患者丈夫单核细胞刺激后的患者淋巴细胞对ＣｏｎＡ 的反应能力显著下降，与未经刺激的细胞相比，Ｐ＜ ０００１ 。同时，患者夫妇的ＭＬＣ上清对无关个体间的ＭＬＣ 具有抑制作用，抑制率为３６７ ％ 。结论：表明同种异体细胞的刺激能诱导出免疫抑制，这一结果与临床习惯性流产患者主动免疫治疗的结果相一致。
Objective:To observe the immune reactivities of patients with recurrent spontaneous abortions after immunotherapy Methods:An improved mixed lymphocyte culture (MLC) was adopted to mimic the clinical immunotherapy The reactivities of the patient′s lymphocytes after stimulated were tested with ConA Results:The reactivities of patient′s lymphocytes to ConA were turned down significantly (P<0 001) after stimulated by their husband′s monocytes And the MLC of unrelated donors could be inhibited by the supernate of MLC of patient′s couples The suppressive rate was 36 7% Conclusion:These results indicated that immunosuppression could be induced by the stimulations of allo mononuclear cells It coincided with the results of clinical immunotherapy of patients with recurrent spontaneous abortions
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第9期427-428,430,共3页
Chinese Journal of Immunology
基金
卫生部资助
关键词
主动免疫治疗
习惯性流产
免疫抑制
Immunotherapy Recurrent spontaneous abortion Immunosuppression
