摘要
目的:分析P53蛋白在三阴性乳腺癌中的表达特点及临床意义。方法:收集2006年6月～2010年10月收治的可手术三阴性乳腺癌85例及非三阴性乳腺癌90例的临床病理资料,回顾性分析P53蛋白在两者中的表达特点。结果:三阴组中,P53蛋白阳性与患者的年龄、淋巴结转移、组织学分级差异均有统计学意义(均P<0.05);非三阴组中,P53蛋白阳性与患者的组织学分级差异有统计学意义(P<0.05)。P53蛋白阳性率在三阴组及非三阴组中分别为63.53%(54/85)及46.67%(42/90),两者之间差异有统计学意义(P<0.05)。结论:三阴性乳腺癌中,P53蛋白阳性提示其恶性程度高,易转移,预后差,可以作为评估三阴性乳腺癌预后的一个重要因素。
Objective： To analyze the expressions and clinical significances of P53 in triple-negative breast cancer（TNBC）.Methods： The clinicopathologic dates of 85 cases of operable TNBC and 90 cases non-triple-negative breast cancer（non-TNBC） treated from June 2006 to October 2010 were collected.The expressions of P53 in TNBC and non-TNBC were summarized and retrospectively analyzed.Results： In the group of TNBC,the positive protein of P53 had all correlation with age,axillary lymph node metastatis and histological grade（P0.05）.In the group of non-TNBC,the positive protein of P53 had correlation with histological grade（P0.05）.In the group of TNBC and the group of non-TNBC,the positive protein of P53 was 63.53%（54/85） and 46.67%（42/90） respectively,so there were obvious difference between them（P0.05）.Conclusion： The positive protein of P53 in TNBC suggests their high degree maliganancy and easy metastasis.The prognosis is poor.They can be taken as an important factor when we predicted its prognosis.
出处
《中国医药导报》
CAS
2011年第13期22-24,共3页
China Medical Herald
关键词
P53
三阴性乳腺癌
转移
预后
P53
Triple-negative breast cancer
Metastasis
Prognosis
