摘要
目的探讨白介素-6(IL-6)、C-反应蛋白(CRP)及D-二聚体在慢性阻塞性肺疾病(COPD)急性加重期中的变化与意义。方法检测48例慢性阻塞性肺疾病急性加重期患者治疗前后和43例健康对照组血清中IL-6,CRP和D-二聚体的水平。结果慢性阻塞性肺疾病急性加重期中IL-6,CRP和D-二聚体治疗前的水平均显著高于治疗后及健康对照组,差别具有显著性意义(P<0.05),D-二聚体与动脉血氧分压(PaO2)成负相关(r=-0.567,P<0.05),与(PaCO2)成正相关(r=0.683,P<0.05)。结论 IL-6与CRP联合检测可作为早期判断COPD急性加重的敏感指标,及时纠正缺氧、解痉及适当的给予抗凝药物治疗,有助于改善患者临床预后。
Objective To investigate the implication and correlation of serum IL-6,C-reactive protein and the plasma D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods The levels of serum IL-6 and CRP,the plasma D-dimer in 48 patients with AECOPD and 43 healthy control subjects were detected.Results The levels of serum IL-6 and CRP,the plasma D-dimer in patients with AECOPD were significantly higher than those in healthy control subjects,there was significant difference between the two groups（P0.05）.the plasma D-dimer level was negatively correlated with PaO2（r=-0.567,P0.05）,The plasma D-dimer level was positively correlated with PaCO2（r=0.683,P0.05）.Conclusions The joint of IL-6 and CRP may be the sensitive indicators of determining exacerbation of COPD early,improvement of hypoxemia,ventilation and the anti-coagulability medicine treatment are benefitial for chronic obstructive pulmonary disease patients.
出处
《医药论坛杂志》
2011年第4期31-33,共3页
Journal of Medical Forum
关键词
慢性阻塞性肺疾病
CRP
IL-6
D-二聚体
Chronic obstructive pulmonary disease
IL-6
C-reactive protein
Plasma D-dimer
