摘要
目的探讨甘精胰岛素、胰岛素泵持续皮下输注对初诊2型糖尿病患者的疗效。方法选择2007年1月至2010年3月180例初诊的2型糖尿病患者,随机分为3组,分别采用甘精胰岛素(A组)、胰岛素泵(B组)及常规口服降糖药物(C组)进行12周的治疗,检测治疗前后血糖、糖化血红蛋白(HbA1c)、胰岛素、C肽水平,计算β细胞功能(Homa-β)、胰岛素抵抗指数(Homa-IR)、血糖曲线下面积(AUCg)、胰岛素曲线下面积(AUCi),比较各项指标的变化。结果 3组患者治疗后血糖、HbA1c、Homa-IR、AUCg均较治疗前降低,胰岛素、C肽、Homa-β及AUCi均较治疗前升高,有显著性差异(P<0.01)。其中A组治疗前后HbA1c为(10.89±2.42)vs.(6.15±1.24),B组(11.42±2.31)vs.(6.23±1.29),C组(11.37±2.50)vs.(7.15±1.39);而A组治疗前后空腹胰岛素(7.14±1.24)μIU/mlvs.(10.03±1.67)μIU/ml,B组(7.20±1.42)μIU/mlvs.(10.34±1.65)μIU/ml,C组(7.01±1.38)μIU/mlvs.(8.94±1.51)μIU/ml。A、B组较C组改变更显著(P<0.05),A、B组间无显著性差异。结论甘精胰岛素和胰岛素泵持续皮下输注均能明显改善初诊2型糖尿病患者的胰岛β细胞功能。
Objective To compare the indexes variations of insulin glargine or insulin pump or oral hypoglycemic drugs in recently diagnosed type 2 diabetes.Methods A total of 180 individuals were randomly divided into three groups：insulin glargine（group A）,insulin pumps（group B） and oral hypoglycemic drugs（group C） for 12 weeks respectively.The data of plasma glucose,glycosylated hemoglobin Alc（HbAlc）,fasting insulin,C peptide,biochemistry index,function index of β-cell（Homa-β）,insulin resistance index（Homa-IR） and area under curve of glucose and insulin before and after the therapy were compared.Results After 12 weeks＇ treatment,the plasma glucose,HbAlc,AUCg,Homa IR were significantly decreased,whereas insulin,C peptide,Homa-β and AUCi were significantly increased（P 0.01）.HbA1c was decreased from（10.89±2.42）% to（6.15±1.24）%（in group A）,（11.42±2.31）% to（6.23±1.29）%（in group B）,（11.37±2.50）% to（7.15±1.39）%（in group C）.And fasting insulin was increased from（7.14±1.24）μIU/mL to（10.03±1.67）μIU/mL（in group A）,（7.20±1.42）μIU/mL to（10.34±1.65）μIU/mL（in group B）,（7.01±1.38）μIU/mL（8.94±1.51）μIU/mL（in group C）.Furthermore,there were more significant changes in group A and group B than group C（P 0.05）,but there was no significant difference between group A and group B.Conclusions The β-cell function of patients with early stage of type 2 diabetes can be improved by use of insulin glargine or insulin pumps.
出处
《北京医学》
CAS
2011年第5期399-402,共4页
Beijing Medical Journal
