摘要
目的:缺血后处理已经在心、肾等器官上广泛应用,进行相关研究进一步探究缺血后处理对皮瓣有否保护作用。方法:健康成年新西兰大白兔,分为3组。A组为给予缺血后处理;B组为再灌注前5min给予A2A阻滞剂SCH58261+缺血后处理。C组,直接应用微血管夹阻断腹壁浅血管持续缺血6h后,恢复正常血供。分别进行中性粒细胞浸润,MPO含量和皮瓣存活率检测。结果:新西兰大白兔完全存活。B、C组相比较,中性粒细胞计数以及MPO含量也未见统计学差别(P>0.005)。实验组皮瓣存活面积比较,B与C相比较,无统计学意义(P>0.005),但是A与B、C相比较,上述指标两两之间都有统计学意义差别(P<0.005)。结论:缺血后处理对皮瓣再灌注损伤有保护作用,该作用可能和A2A受体性质有关。
Objective The ischemia postconditioning is widely used for the protection of the heart,kidney,a further study is done to explore the protection of the ischemia postconditioning on the skin flap.Methods The adult newzlend rabbits are divided into 3 group.A group is provided with ischemia postconiditoning;B group is provided with A2A inhibitor SCH58261 plus ischemia postconditioning.C group is provided with direct ischemia with microvascular clamp.The study includes neutrophil cell infiltration,content of MPO and the survival of skin flap.Conclusion The rabbits all survived.No difference existed between B and C group about neutrophil count and content of MPO（P0.005）.No difference was found about the skin flap survival.But about the above three parameters,A group was found to have significance between B and C group.Conclusion Ischemia postconditioning can protect the skin flap which may be attributed to the role of the A2A receptor.
出处
《中国美容医学》
CAS
2011年第3期416-418,共3页
Chinese Journal of Aesthetic Medicine
