摘要
干细胞是一类具有自我更新和多向分化潜能的特殊细胞。研究发现,干细胞的生物学行为高度依赖于其所处的微环境(niche)。Niche对干细胞的作用分为细胞与细胞之间的直接作用和基质及众多细胞因子对干细胞的间接作用,涉及多条信号转导通路及其相互作用。本文主要介绍骨髓干细胞的niche对间充质干细胞(MSC)的调控,并探讨MSC向心肌细胞分化的调控机制。
Stem cells are the special cells of self-renewal and differentiation potential.Recent studies found that the biological behaviors of stem cells are highly dependent on their microenvironment（niche）.There are two roles of niche on stem cells：the direct effects between cell contacts,and the indirect effects such as matrix and cytokines which involve in several signal transduction pathways and their cross-talks.Here,we mainly describe the effects of bone marrow niche on mesenchymal stem cells（SMC）,and the regulatory mechanisms of MSC differentiation into myocardial cells.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2011年第2期141-145,154,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(30772142
81070103)
关键词
干细胞
微环境
心肌细胞
细胞分化
stem cell
niche
myocardial cell
cell differentiation
