摘要
目的观察善宁联合洛派丁胺治疗化疗相关性腹泻的疗效。方法选择发生化疗相关性腹泻3级以上的肿瘤患者97例,给予善宁0.1mg皮下注射,q8h治疗,并口服洛派丁胺,首次4mg,其后每4h口服2mg。记录患者一般状况、腹泻次数及用药反应。结果 97例均可评价疗效,治疗总有效率为91.75%(89/97),其中73例(75.26%)在3d之内症状完全控制,6例1周后腹泻仍未控制,判断为无效。其中1例死于腹泻并发症。结论善宁联合洛派丁胺治疗化疗相关性腹泻疗效显著,值得临床进一步应用。
Objective To study the effectiveness of sandostain and loperamide for chemotherapy-induced diarrhea.MethodsNinty-seven patients with grade 3 diarrhea with sandostain（0.1mg i.h,q8h）,and loperamide 4mg at the first time and then 2mg each four hours orall.Result97 patients were evaluable for response.The overall response rate was 91.75%（89/97）,diarrhea was controlled in 3 days in 89 patients.Diarrhea was not controlled in 6 patients even until the seventh day,which were regarded as treatment failure.1 patient died from diarrhea.ConclusionSandostain and loperamide can control chemotherapy-induced diarrhea significantly.
出处
《中国医药指南》
2011年第12期192-193,共2页
Guide of China Medicine
关键词
善宁
洛派丁胺
化疗相关性腹泻
Sandostain
Loperamid
Chemotherapy-induced diarrhea
