摘要
目的观察甲地孕酮(MA)对晚期癌症厌食-恶病质患者疗效。方法将岳阳市第一医院2008年6月至2010年3月住院晚期癌症患者80例随机分为治疗组(MA加支持治疗)40例和对照组(单纯支持治疗)40例,观察两组食欲、体质量、KPS评分的变化。结果治疗组食欲改善35例(87.5%)、体质量增加28例(70%)、KPS评分增加30例(75%),对照组食欲改善12例(30%)、体质量增加6例(15%)、KPS评分增加5例(12.5%),两组间比较差异有统计学意义(P<0.05),未见明显不良反应。结论 MA能显著改善晚期恶性肿瘤患者厌食症状及恶病质,并能通过改善体质从而获得进一步抗肿瘤治疗的机会。是晚期恶性肿瘤患者有效的辅助治疗药物。
Objective To observe the clinical observation of megestrolacetate in advanced cancer anorexia-cachexia.Methods80 patients with cancer anorexia-cachexia into the treatment group（40 patients）treated with MA plus supportive care and control group（40 patients） treated with supportive care only.The changes of appetite,weight,and KPS were observed in each group.ResultsIn the treatment group,35 cases（87.5%） got appetite improving,28cases（70%） gained weight,30 cases（75%） got KPS score increasing.In the control group,12cases（30%）got appetite improving,6 cases（15%）got KPS score increasing.The differences in two groups were significant（P0.05）.There was no obvious toxicity.ConclusionMegestrolacetate can significantly improve symptoms of advanced cancer patients with anorexia and cachexia moreover it can make patients be physical in order to improve access to opportunities for further anti-cancer therapy,is a useful assisted therapy in patients with advanced cancer treatments.
出处
《中国医药指南》
2011年第12期20-21,共2页
Guide of China Medicine
关键词
甲地孕酮
晚期癌症
厌食-恶病质
Megestrolacetate
Advanced cancer
Anorexia-cachexia
