摘要
[目的]了解肿瘤病人化疗前后消化道症状的变化。[方法]用自行设计的化疗消化道症状量表对100例肿瘤静脉化疗病人化疗前后消化道症状进行纵向观察;分析化疗前、化疗第1个24 h、化疗第2个24 h消化道症状发生率、严重程度的差异以及相互关系。[结果]在3个时相点食欲减退、口腔/咽喉干燥、味觉异常的发生率和严重程度均居前3位,口腔/咽喉疼痛、烧心/胃灼热、腹泻的发生率和严重程度均较低。在化疗第1个24 h和第2个24 h,食欲减退、恶心、呕吐、味觉异常、呃逆、胃/腹胀、便秘7项症状的发生率和严重程度均高于化疗前;化疗第1个24 h与第2个24 h比较,消化道症状发生率和症状总分差异无统计学意义,但食欲减退、味觉异常、口腔/咽喉干燥、便秘4项症状明显加重。在消化道症状总分上,化疗前对化疗第1个24 h和第2个24 h均有显著预测力。[结论]化疗后消化道症状发生率和严重程度总体上高于化疗前,但消化道各种症状的变化轨迹并不相同;化疗前消化道症状的发生情况与化疗后消化道症状整体负荷密切相关。临床医护人员应重视化疗前消化道症状的评估和控制,为化疗后消化道症状的预测、筛选、预防和干预提供参考。
objective：To know about the difference of gastrointestinal tract symptoms（GIS） of tumor patients before and after chemotherapy.Methods：A total of 100 tumor patients treated with intravenous chemotherapy were vertically investigated with self-designed chemotherapy-related GIS inventory.The prevalence,severity degree,and correlations of GIS at three time points（before chemotherapy,the first 24 h after chemotherapy,the second 24 h after chemotherapy） were compared.Results：At three time points,anorexia,dry mouth/throat,and dysgeusia ranked top three symptoms for both incidence and severity;the incidence and severe degree of mouth/throat pain,heartburn,and diarrhea were lower.At the first 24 h and the second 24 h after chemotherapy,the incidence and severe degree of the nausea,vomiting,taste abnormalities,hiccups,stomach/abdominal distension,constipation 7 symptoms were higher than before chemotherapy.Compared with the first 24 h,at the second 24 h after chemotherapy,just the severity of anorexia,dysgeusia,mouth/dry throat and constipation were more severe,but no statistical significant difference in incidence and the total score of GIS.Compared to the total score of the GIS after chemotherapy,the score before CA was a significant prognostic factor.Conclusion：The incidence and severity Degree of GIS before chemotherapy are higher than that after chemotherapy as a whole,but various GIS progresses in diverse trajectory;the occurrence of GIS before chemotherapy is closely related with the integrated GIS burden after chemotherapy;therefore,in the clinical symptom management,good assessment and control of the GIS before chemotherapy should be focused in the chemotherapy-related GIS prognosis,screening,prevention and intervention.
出处
《护理研究（中旬版）》
2011年第4期947-950,共4页
Chinese Nursing Researsh
基金
重庆市医学科研计划基金资助项目
编号:2010-2-311
关键词
肿瘤病人
化疗
消化道症状
症状进展
tumor patients
chemotherapy
gastrointestinal tract symptom
symptom progression
