摘要
目的：观察甘露聚糖肽联合阿片类药物治疗癌痛的临床效果。方法：采取随机、对照试验方法,64例晚期恶性肿瘤伴疼痛的患者,年龄37~69岁,VAS评分≥6,随机分为两组：吗啡组32例,甘露聚糖肽＋吗啡组32例。达到疼痛缓解时（VAS评分≤3分）维持给药直至观察终点,然后比较治疗前后的疼痛缓解程度、吗啡日均消耗量、生活质量的改变。结果：与治疗前相比,两组癌痛均有不同程度的缓解,联合用药组总缓解率高于单药组（P〈0.05）;联合用药组的吗啡日均消耗量比单药组少（P〈0.05）;联合用药组患者生活质量较单药组明显提高。结论：甘露聚糖肽联合吗啡能有效地控制癌痛,减少吗啡的用量,并能提高患者生活质量。
Objective：To investigate the efficacy of Mannatide combined opioid for cancer pain.Methods： Sixty four patients who suffered pain of cancer disease,VAS scores≥6,age ranged from 37 to 69,were randomized into two groups： one group was administered with only opioid（32 patients）,the other was given opioid plus mannatide（32 patients）.We recorded the pain score by VAS,dose consumption,side effect,quality of life,detected them ediators releated to pain.Results： Pain relief was better in the group opioid plus mannatide compared with the single opioid group（P 0.05）;the morphine consumption of group opioid plus mannatide was less more than group single opioid（P 0.05）,and mannatide reduced opioid related adverse effects;and them editors releated to pain of two groups after treatment were lower than before（P0.05）.Patient satisfaction were significantly better after treatment than those of the control group（P0.05）.Conclusion： The synergistic effect of mannatide andopioid can effectively reduce cancer pain,morphine consumption,and morphine related adverse effects of patiens who suffer from cancer pain.
出处
《内蒙古医学杂志》
2011年第2期143-145,共3页
Inner Mongolia Medical Journal
