摘要
背景:颅颌面骨为不规则骨,具有复杂的三维立体结构。对于颅颌面的骨缺损,进行个性化精确修复十分重要。计算机辅助设计、计算机辅助制造和激光扫描技术是近年发展起来的高新技术,通过这些技术可以实现颅颌面个性化骨形态结构的三维仿真。目的:设计一个由计算机辅助设计、计算机辅助制造和激光扫描技术组成的数字医学系统,以实现生物材料对下颌骨髁突等形态的三维模拟。方法:通过CT扫描获得犬头颅影像信息,计算机辅助设计、计算机辅助制造实现下颌骨形态的三维重建影像,影像数据输入三维打印机,快速成型获得下颌骨髁突的树脂阳模。阴阳模转换获得相应石膏阴模,聚羟基乙酸/聚乳酸阴模内成型,激光三维表面扫描检测聚羟基乙酸/聚乳酸支架和影像原型匹配的精确度。结果与结论:聚羟基乙酸/聚乳酸支架和影像原型匹配的精确度检测结果显示,当测试点误差小于1.0mm时,复合率大于95%。提示通过这套数字医学系统,可实现颅颌面骨形态结构生物材料的三维仿真,为下颌骨骨缺损的精确修复打下基础。
BACKGROUND：Craniomaxillofacial bone is irregular and has a subtle three-dimensional （3D） structure,and individualized repair of bone defects is very important.Computer-aided design （CAD）,computer-aided manufacturing （CAM）,rapid prototyping,as well as laser scanning have therefore been applied in craniomaxillofacial surgery.OBJECTIVE：To develop a novel digital medical support system that enables us to custom-make scaffolds to repair craniomaxillofacial bone defects using CAD/CAM and rapid-prototyping technology.METHODS：We created positive molds using CT data,CAD/CAM and a rapid prototyping method using 3D printing.Custom-made poly （glycolic acid） （PGA） and polymers poly （lactic acid） （PLA） scaffolds were prefabricated by a positive-negative mold interchange technique.A laser scanning system was used to evaluate the accuracy of the PGA/PLA scaffold.RESULTS AND CONCLUSION：The mean error was smaller than 0.3 mm and confidence was greater than 95% when the error was smaller than 1 mm.This pilot study suggests that custom-made PGA/PLA scaffolds could accurately reconstruct craniomaxillofacial bone injuries by our digital medical support system.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第9期1562-1565,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金(30700873)"定制型全功能组织工程下颌支的在体构建及缺损修复的实验研究"~~
