摘要
目的:系统探讨女性围绝经期情绪障碍的影响因素。方法:62例经Zung氏焦虑自评量表(SAS)、Zung氏抑郁自评量表(SDS)筛选后具有抑郁和/或焦虑(SAS>50和/或SDS>53)的围绝经期女性患者构成病例组,入组患者均在中山大学附属第三医院心理科病房接受住院观察和治疗;60例SAS<50和SDS<53的围绝经期健康女性构成对照组,对照组来源于本院教职工及周边单位来三院体检者;2组均进行汉密尔顿焦虑量表(HA-MA)、汉密尔顿抑郁量表(HAMD)、生活事件量表(LES)、艾森克人格特征问卷(EPQ)及应付方式问卷的评估,并于清晨8点空腹状态下采取外周静脉血进行雌激素(E2)、5-羟色胺(5-HT)和去甲肾上腺素(NE)水平的测定。结果:病例组与健康对照组之间的负性生活事件、人格特征、应付方式及雌激素(E2)和五羟色胺(5-HT)的浓度存在显著差异;病例组的多元逐步回归分析发现:5-HT、NE和E2的水平与HAMD评分呈负相关,负性生活事件、自责、神经质等社会心理因素与HAMD评分呈正相关。结论:女性围绝经期情绪障碍的发生是多种社会心理因素和生物学因素综合作用的结果。
AIM： To explore the causes of women emotional disorder in perimenopause.METHODS： Sixty-two perimenopausal women with emotional disorder screened by Zung self-rating anxiety scale（SAS） and Zung self-rating depression scale（SDS） were selected as case group,and they were admitted to the psychological ward to accept observation and therapy in The Third Affiliated Hospital of Sun Yat-sen University.Sixty healthy perimenopausal women without emotional disorder,from the hospital staffs and neighboring unit,also screened by SAS and SDS,were enrolled into control group.Every woman must accept the assessment of the rating scales[including Hamilton anxiety scale（HAMA）,Hamilton depression scale（HAMD）,Eysenck personality questionnaire（EPQ）,lift event scale（LES） and coping style questionnaire] one time after registration.The peripheral venous blood samples at 8 o＇clock AM were collected for detection of estradiol（E2）,serotonin（5-HT） and norepinephrine（NE）.RESULTS： Significant differences between case group and control group were observed in negative life events,EPQ,coping style and the concentration of E2 and 5-HT.Multiple stepwise regression analysis of the information from case group indicated that the levels of 5-HT,NE and E2 showed to be negatively correlated with HAMD total score,and negatively life event,reproachment,nervousness appeared to be positively correlated with HAMD total score.CONCLUSION： Women emotional disorders in perimenopause are the comprehensive result of multiple social-psychological factors and biological factors.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第3期599-602,共4页
Chinese Journal of Pathophysiology
基金
广东省医学科研基金资助项目(No.A2009199)
