摘要
目的检测脑卒中存活者5-羟色胺运载体（SERT）中5-羟色胺转运体基因启动子区多态性（5-HTTLPR）、rs25531多态性是否与卒中后抑郁（PSD）相关。方法选取70例脑卒中后抑郁患者为实验组，70例脑卒中后无抑郁患者为对照组，收集两组患者唾液与血液样本提取DNA进行基因分析。结果5-HTTLPRs／s基因携带者发生PSD几率比1／1或1／X1高2倍，rs25531基因与PSD无相关性。结论5-HTTLPR多态性与PSD发生相关，进一步证实SERT基因多态性在生物心理社会学应激中的作用。
Objective To determine whether the 5 - HTTLPR, rs25531 polymorphisms of SERT were associated with poststroke depression（PSD） in stroke survivors. Methods Seventy- five stroke survivors with PSD and 75 non - depressed stroke survivors, blood or saliva samples were collected from each participant for DNA extraction and genotyping. Results Subjects with the 5 - HTFLPR s/s geno- type had three- fold higher odds for PSD compared to 1/1 or L/X1 genotype carriers （ OR 3. 1, 95% CI 1.2 -8.3）. An association of rs25531 with PSD could not be shown. Conclusions The 5 -HTFLPR but not the rs25531 , polymorphisms of SERT are associated with PSD in stroke survivors. This gives further evidence for a role of SERT polymorphisms in mediating resilience to biopsyehosocial stress.
出处
《中国实用医刊》
2011年第9期31-33,共3页
Chinese Journal of Practical Medicine
关键词
5-羟色胺运载体
多态性
卒中后抑郁
5 -serotonin transporter
Polymorphism
Post stroke depression
