摘要
目的:探讨二尖瓣环钙化(MAC)与颈动脉粥样硬化的关系。方法:采用高频超声对138例MAC患者[MAC组,含重度MAC患者(SMAC组)45例,非重度MAC患者(NSMAC组)93例]及90例同期进行检查无MAC者(对照组)的颈动脉进行检测,计算颈动脉的狭窄幅度。结果:与对照组比较,NSMAC组颈动脉斑块发生率、狭窄的发生率均显著增高(P<0.05),SMAC组上述指标比较更为显著(P<0.05);NSMAC组及SMAC组颈动脉内膜中层厚度(IMT)显著高于对照组(P<0.05),SMAC组颈动脉IMT与NSMAC组比较差异有显著差性;多因素逐步回归分析表明MAC可以作为颈动脉狭窄≥50%有意义的预测因子(P<0.01)。结论:通过对MAC的检测,能够预测颈动脉粥样硬化的存在。
Objective To determine whether there is an association between the presence of mitral annular calcification （MAC） and carotid artery atherosclerotie disease. Methods 138 patients with MAC diagnosed by transthoracic echocardiography and 90 controls without MAC underwent carotid artery ultrasound. Result （1）Compared with the control group ,the NSMAC group showed a significantly higher prevalence of plaque（54.84% vs 27.78%, P 〈 0.05）of bilateral carotid artery.（2） More significant difference was found in the SMAC subgroup in rates of carotid atherosclerotic plaque （80.00% vs 27.78%, P 〈 0.05）of bilateral carotid artery. （3） Carotid IMT was significantly thicker in the NSMAC group and SMAC subgroup than that in the control group respectively. Carotid IMT of SMAC subgroup was more significantly thicker than that in the MAC group [（2.15±0.75）mm vs （1.51±0.33）mm, P = 0.002; （2.76：±0.59）mm vs （1.51±0.33）mm, P=0.000]. （4）Linear regression analysis showed that MAC can be served as a significant predictor of carotid atherosclerotic disease （stenosis of ≥ 50%, P 〈 0.01 ）. Conclusions MAC may be an important marker for atherosclerotic disease of the carotid arteries.
出处
《实用医学杂志》
CAS
北大核心
2011年第9期1588-1590,共3页
The Journal of Practical Medicine
