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丙型肝炎病毒与HBV、CMV共同感染测定的临床意义 被引量:1

CLINICAL SIGNIFICANCE OF COMBINED INFECTIONS OF HEPATITIS C VIRUS TOGETHER WITH HEPATITIS B VIRUS OR CYTOMEGALOVIRUS
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摘要 探讨丙型肝炎( 简称丙肝) 病毒与HBV、CMV 混合感染对临床某些疾病的诊断价值.对221 例临床选择病例的HCV M、HBV M 和CMV M 联合检测,发现三种病毒共同感染者5例,检出率为2 .3 % (5/221) ;5 例均为血液透析病人.HBV 与HCV 两种病毒共同感染者47 例(47/221 ,21 .3 % ) ,血液透析组为51 .2 % (22/43) ;其后依次为慢性丙型肝炎组29 .6 % (8/27) ;肝细胞癌组21 .9 % (7/32) ;白血病组21 .4 % (3/14) 和急性输血后丙型肝炎组11 .1 % (5/45) ;其他肿瘤组、普通住院患者组分别为3 .7 % (1/27) 和3 .0 % (1/33) .HCV 与CMV 共同感染者中,慢性丙型肝炎组达33 .3 % (9/33) ;肝细胞癌组为28 .1 % (9/32) ;其后依次为血液透析组27 .9 %(12/43) 和急性输血后丙型肝炎组24 .4 % (11/45) .白血病组没有没有发现2 种病毒混合感染者.提示血液透析是传播肝炎病毒的一条重要途径;HCV 与CMV 的混合感染,仅多见于与HCV The clinical significance of combined infections of Hepatitis C Virus (HCV), together with Hepatitis B Virus (HBV) or Cytomegalovirus (CMV) for certain diseases was explored in this study.221 serum samples were collected from the patients with acute post transfusion Hepatitis C, chronic Hepatitis C or other diseases. Enzyme linked immunosorbent assays (ELISA) were employed for all the determinations of serum markers, i.e., HCV:anti HCV IgG,HBV:HBsAg, anti HBs,HBeAg, anti HBe and anti HBc, and CMV: anti CMV IgG and IgM. The results showed 5 patients (5/221,2.3%) who were under going hemodialysis were infected by all the 3 viruses simultaneously. 47 patients were infected by both HCV and HBV. Among them, the patients undergoing hemodialysis had the highest positive rate (51.2%,22/43). The positive rates in the other patient′s group were 29.6%(8/27) for chronic Hepatitis B, 21.9%(7/32) for hepatocellular cancer, 21.4%(3/13) for leukemia, 11.1%(5/45) for acute post transfusion Hepatitis C, 3.7% (1/27) for other tumors and 3.0%(1/33) for other diseases respectively. 41 patients were infected by both HCV and CMV and the the positive rates were 33.3%(9/33) for chronic Hepatitis B, 28.1%(9/32) for hepatocellular cancer 27.9% (12/43) for hemodialysis, 24.4% (11/45) for acute post transfusion Hepatitis C respectively, but no one in leukemia group. It suggested that Hemodialysis was an important pathway for transmission of hepatitis virus. The combined infections of HCV and CMV were only found in the patients who suffered from the diseases closely associated with HCV infection.
出处 《南京大学学报(自然科学版)》 CAS CSCD 1999年第5期639-642,共4页 Journal of Nanjing University(Natural Science)
基金 南京军区联勤部卫生部重点课题基金
关键词 丙型肝炎病毒 HBV CMV 感染 混合感染 测定 hepatitis C cytomegalovirus HBV
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