摘要
目的探讨残胃癌的临床病理特征和预后影响因素。方法对1992年1月至2008年7月138例残胃癌患者的临床病理及生存资料进行回顾性分析，其中男性122例，女性16例，平均年龄61．5岁，距首次手术时间平均为21．9年。结果本组残胃癌病理特征以未分化型（83．3％）、BorrmannⅢ＋Ⅳ型（92．7％）为主，肿瘤直径〉4ClTI者（75．7％）多见，其手术切除率（72．4％）及根治性切除率（59．4％）均低于一般胃癌。1、3、5年生存率分别为59．2％、30．1％、14．2％，总体中位生存期19．4个月。单因素分析中组织学类型、Borrmann分型、肿瘤直径、TNM分期、浸润深度、淋巴结转移数、远处转移及治疗方式是影响预后的相关因素。多因素分析中TNM分期、浸润深度、远处转移及治疗方式是影响预后的独立因素；根治性切除者中位生存期（36个月）明显长于姑息性切除（8个月）、短路手术及其他组（5个月，P〈0．05），行联合脏器切除的无远处转移T4期患者生存期为18．6个月，较无联合脏器切除组明显延长（P〈0．05）。结论残胃癌恶性程度较高、预后较差，TNM分期、浸润深度、远处转移及治疗方式是影响预后的独立因素，早期诊断及根治性切除是改善其预后的羊键．
Objective To explore the clinicopathological characteristics and prognostic factors of gastric stump cancer（GSC）. Methods The clinical data of 138 patients with GSC treated from January 1992 to July 2008 were reviewed and analyzed. The patients included 122 males and 16 females with a mean age of 61.5 years, and the mean interval between the initial operation and second diagnosis was 21.9 years. Results The endoscopy and pathological examination showed Borrmann Ⅲ/IV in 127 （92.7%） patients and undifferentiated carcinoma in 115 （83.3 % ） patients. The resectability and radical reseetability rate were 72.4% and 59.4%. The 1-, 3- and 5-year survival rates was 59. 2% , 30. 1% and 14.2% , respectively. The median overall survival time was 19. 4 months. Univariate Log-rank test indicated that Borrmann type, histological type, tumor diameter, TNM stage, depth of invasion, number of metastatic lymph node, distant metastasis and option of treatment were significant prognostic factors for GSC. While TNM stage, depth of invasion, distant metastasis and option of treatment were prognostic factors on multivariable analysis. The median survival time of patients underwent radical resection was significantly longer（ 36 months） than that of patients received palliative resection（8 months, P 〈 0. 05 ） and chemotherapy only （5 months, P 〈 0. 05 ）. Among patients with a tumor of T4 stage, the median survival time was statistically prolonged by combined evisceration （ 18.6 months）when compared with the patients received palliative surgery. Conclusions TNM stage, depth of invasion, distant metastasis and option of treatment are independent prognostic factors for GSC. Early diagnosis and radical resection may play an important role in improving the prognosis of GSC.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2011年第3期204-207,共4页
Chinese Journal of Surgery
关键词
胃肿瘤
预后
因素分析
统计学
Stomach neoplasms
Prognosis
Factor analysis, statistical
