摘要
目的:比较计算机辅助细胞学检测(computer-assisted cytological test,CCT)、液基细胞学检查(liquid-basedcytological test,LCT)、LCT联合二代杂交捕获系统(hybrid captureⅡ,HC2)HPV DNA检测在宫颈癌筛查中的灵敏度和特异度。方法:CCT检测的全部病例与LCT检测的部分病例为回顾性病例。HPV DNA检测选用HC2法,剩余标本继续做LCT检测。结果:HC2 HPV DNA结合LCT检查的敏感性显著高于CCT及LCT两种检查方法检查的敏感性(P<0.05)。CCT检测宫颈癌的特异性是88.14%,LCT的特异性是93.78%,LCT联合HC2 HPV DNA检测的特异性是100.00%。三者特异性比较差异均具有统计学意义(P<0.05)。结论:CCT和LCT是目前有效的宫颈癌筛查手段。HC2 HPV DNA检查结合LCT是筛查宫颈癌及癌前病变最好的方法,其阴性预测值几乎达到100%。
Objective：To compare the sensitivity and specificity of computer-assisted cytological test（CCT）,liquid-based cytological test（LCT） and LCT combined with hybrid capture Ⅱ（HC2） HPV DNA detection in screening of cervical cancer.Methods：All the cases receiving CCT and partial cases receiving LCT were retrospective cases.HC2 was used for HPV DNA detection,and the residual cases received LCT.Results：The sensitivity of LCT combined with HC2 HPV DNA detection was significantly higher than those of CCT and LCT（P0.05）.The specificities of CCT,LCT and LCT combined with HC2 HPV DNA detection in screening of cervical cancer were 88.14%,93.78% and 100.00%,respectively,there was significant difference among the three methods（P0.05）.Conclusion：At present,CCT and LCT are effective screening methods of cervical cancer.HC2 HPV DNA detection combined with LCT is a best method to screen cervical cancer and precancerous lesion,its negative predictive value is almost 100%.
出处
《中国妇幼保健》
CAS
北大核心
2011年第12期1888-1890,共3页
Maternal and Child Health Care of China
关键词
宫颈癌
计算机辅助细胞学检测
液基细胞学检查
人乳头状瘤病毒
筛查
Cervical cancer
Computer-assisted cytological test
Liquid-based cytological test
Human papillomavirus
Screening
