摘要
目的调查武汉地区内科临床分离菌对抗菌药物的耐药状况。方法收集１９９６年武汉地区１３所医院内科分离的致病菌，药敏试验采用Ｋ－Ｂ法。用ＷＨＯＮＥＴ－３软件进行数据分析。结果共收集致病菌２０１０株，革兰阳性球菌４４４株（２２１％），革兰阴性杆菌１５６６株（７７９％），以大肠杆菌、铜绿假单胞菌、克雷伯菌属最多见。３０７％金黄色葡萄球菌和２７８％凝固酶阴性葡萄球菌耐苯唑西林。可疑产超广谱β－内酰胺酶的克雷伯菌属、大肠杆菌阳性率分别为１５２％、１７７％。亚胺配南、头孢他啶、阿米卡星、环丙沙星对革兰阴性杆菌抗菌作用最强。结论临床细菌耐药性日益严重，各医院应开展细菌耐药性监测，强调临床合理应用抗菌药物。
Objective\ To study the antimicrobial resistance of clinical isolates from internal medicine in Wuhan area.Method\ Bacterial susceptibility test was carried out by using Kirby-Bauer method.A WHONET-3 computer software was used to analyze the results.Result\ Total of 2010 clinical isolates,including 444 strains (22 1%) of Gram positive cocci and 1566 strains (77 9%) of Gram negative bacilli were tested against 17 antimicrobial agents.E.coli,P.aeruginosa and Klebsiella were the main microorganism.30 7% of S.areus and 27 4% of the coagulase negative staphylococci (CNS) were resistant to oxacillin.15 2% of Klebsiella and 17 7% of E.coli were suspected to produce extended-spectrum β-lactamase(ESBL).The most active agents against Gram negative organisms were imipenem,ceftazidime,Amikacin and Ciprofloxacin.Conclusion\ It is suggested that there is an urgent need for surveillance of bacterial resistance in different hospitals and rational use of antimicrobial agents should be emphasised during clinical therapy.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
1999年第8期472-474,共3页
Chinese Journal of Practical Internal Medicine
基金
卫生部国际交流中心-默沙东科研基金
关键词
抗药性
微生物
细菌
抗菌素
Drug resistance\ Microorganism\ Bacteria
