摘要
目的探讨影响夫精宫腔内人工授精临床妊娠率的因素。方法对接受夫精宫腔内人工授精治疗的345例不孕患者766个周期的临床资料进行回顾性分析，主要比较自然周期和促排卵周期、宫腔内人工授精周期数、患者年龄、不孕年限与临床妊娠率的关系。结果766个周期宫腔内人工授精中临床妊娠99周期，临床周期妊娠率为12．92％；≤30岁、31～35岁和〉35岁妊娠率分别为16．23％、13．85％和3．60％；自然周期、克罗米芬周期、尿促性素周期（尿促性素／克罗米芬＋尿促性素）的妊娠率分别为12．44％、11．03％和20．88％；重复周期宫腔内人工授精临床妊娠结局无显著性差异（x2=1．75，P〉0．05）。结论〉35岁女性宫腔内人工授精的妊娠率明显降低；适当应用尿促性素促排卵可提高宫腔内人工授精的临床妊娠率；重复周期对宫腔内人工授精临床妊娠率无明显影响。
Objective To investigate and analyze factors that influence clinical pregnancy rate of infertile women after intrauterine insemination（IUI） with husband＇ s sperms. Methods The clinical data of 345 infertile women undergoing 766 IUI cycles were analyzed retrospectively. Relationships between numbers of natural cycle （ NC ）, ovulation induction cycle, IUI cycle, age of infertile women, infertility years and clinical pregnancy rate were studied. Results Among 766 cycles of IUI, number of clinical pregnancy cycle was 99 and the cycle pregnancy rate was 12.92%. The pregnancy rates among women below 30 years of age, aged 30-35 years and aged beyond 35 years were 16.23% , 13.85% and 3.60% respectively. The pregnancy rates of NC, clomiphene cycle （ CC ） and human menopausal gonadotropin （ HMG）/CC ＋ HMG cycle were 12.44%, 11.03% and 20.88% respectively. There was no correlation between repeated IUI cycle and pregnancy outcome （X2 =1.75 ,P 〉 0.05 ）. Conclusion The clinical pregnancy rate among those infertile women aged beyond 35 years is significantly low. The proper use of HMG in ovulation induction can improve the clinical pregnancy rate after IUI with husband＇ s sperms. There is no correlation between repeated IUI cycle and clinical pregnancy rate.
出处
《中国妇幼健康研究》
2011年第2期195-197,共3页
Chinese Journal of Woman and Child Health Research
关键词
宫腔内人工授精
临床妊娠率
促排卵
年龄
intrauterine insemination （IUI）
clinical pregnancy rate
ovulation induction
age
