摘要
目的观察早期干预对缺氧缺血性脑病患儿的疗效、旨在降低残障率。方法2005年12月-2010年2月在咸阳市儿童医院新生儿科住院治疗并来儿保康复科做早期干预的缺氧缺血性脑病患儿，排除先天畸形、先天性遗传代谢病，分为干预组39例与对照组28例，干预组从新生儿期即进行早期干预，对照组只进行常规喂养指导，未接受早期干预。两组患儿均在3、6个月进行Gesell发育筛查。结果在3个月时进行Gesell发育筛查，干预组在应人能、动作能方面优于对照组，差异具有统计学意义（t值分别为1．73和1．80，均P〈0．05），但在应物能和语言能上，两组经比较差异不具有统计学意义。在6个月时干预组在应人、应物语言、动作4个方面与对照组经比较差异均具有统计学意义（t值分别为11．58、5．51、3．95和6．53，均P〈0．05）。患儿1岁时，干预组较对照组惠儿脑瘫例数明显减少，差异有统计学意义（r=4．68，P〈0．05）。结论早期干预可明显改善缺氧缺血性脑病患儿预后，降低残障的发生。
Objective To observe therapeutic effect of early intervention for children with hypoxic-ischemic encephalopathy （HIE） and to reduce disability rate of the disease. Methods 67 children with HIE who admitted to department of neonatology of our hospital and were excluded congenital malformations and hereditary and metabolic diseases in a period from Dec. , 2005 to Feb. , 2010 were divided into early intervention group （ n = 39） and control group （ n = 28 ）. The children with HIE in the early intervention group received early intervention from the neonatal period and the children in the cotrol group were just fed conventionally and didn＇ t receive any interventions. At 3 months and 6 months of age, the children in the two groups were assessed with Gesell Developmental Diagnosis Scale （GDDS）. Results At 3 months of age, the GDDS scores in person-reacting ability and action ability of the children in the early intervention group were higher than those in the control group and there were significant differences between the two groups （ t = 1.73, 1.80 respectively, both P 〈0.05）, while in GDDS scores in material-reacting ability and language ability there were no significantl differences between the two groups. At 6 months of age, the GDDS scores in all four domains of the children in the early intervention group were higher than those in the control group and there were significant differences between the two groups （t = 11.58, 5.51, 3.95, 6.53 respectively, all P 〈 0.05）. At 1 year of age, the number of children with cerebral palsy in the intervention group was significantly less than the control group （X2 = 4. 6752, P 〈 0.05）. Conclusion Early intervention can improve prognosis of children with HIE and reduce incidence rate of disability.
出处
《中国妇幼健康研究》
2011年第2期172-175,共4页
Chinese Journal of Woman and Child Health Research
关键词
早期干预
缺氧缺血性脑病
脑瘫
预防
early intervention
hypoxic-ischemic encephalopathy （HIE）
cerebral palsy
prevention
