摘要
目的:探讨晚期胃肠道肿瘤中心静脉置管时辰化疗的临床疗效与护理方法。方法:将128例晚期胃肠道肿瘤患者随机分为时辰化疗组与常规化疗组各64例,时辰化疗组应用专用软件编制时辰化疗输液电脑程序,导入微电脑泵,由专门护士根据医嘱配置化疗药物注入专用输液袋,应用法国AGETTANT公司生产的"Melodie"多通道编程输液泵,按医嘱准时开启时辰化疗泵;常规化疗组应用中心静脉置管,遵医嘱配置化疗药物常规输液化疗。两组均选择L-OHP、5-Fu和CF三药组成联合化疗方案。结果:时辰化疗组在静脉炎发生率、近期疗效、毒副反应、生活质量评估等方面疗效明显优于常规化疗组(P<0.05)。结论:中心静脉置管时辰化疗操作简便,提高了临床疗效和患者生活质量。
Objective： To investigate the clinical therapeutic effect of chrono - chemotherapy with central venous catheter and nursing care in the treatment of patients with advanced gastrointestinal cancer. Methods： 128 patients with advanced gastrointestinal cancer were randomly divided into chrono - chemotherapy group and conventional chemotherapy group （ 64 patients for each group）. ＂Melodie＂ multi -channel infusion pump made in France was applied to the patients by following computerized programs worked out by specific software of chrono - chemotherapy in the chrono - chemotherapy group, the nurses prepared chemotherapeutics according to doctor＇s prescription and injected it into infusion bag and open the pump on time; the patients in the conventional chemotherapy group received conventional chemotherapy with central venous catheter. The same combination chemotherapy formula prepared by L- OHP, 5 -Fu and CF was used in both groups. Results： The incidence of phlebitis, toxic and adverse reaction were less and the short - term therapeutic effect and quality of life of the patients were significantly better in the chrono - chemotherapy group than the conventional chemotherapy group （ P 〈 0. 05 ）. Conclusion： The chrono - chemotherapy is easy and simple to be operated and can improve the clinical therapeutic effect and patient＇s quality of life.
关键词
肿瘤
中心静脉置管
时辰化疗
护理
Cancer
Central venous catheter
Chrono - chemotherapy
Nursing
