摘要
目的:研究胺碘酮(AM)预防成人肥厚心肌体外循环术后心律失常的效果并评估其安全性。方法:将72例符合条件的患者分为两组,胺碘酮组(AM组)和对照组(C组),AM组在主动脉开放前30min静注AM5mg/Kg(最大量300mg),继以0.5mg/min维持72h。C组以等容量的生理盐水替代。比较两组间自动复跳率和各种心律失常发生率的差异。结果:AM可以有效提高自动复跳率,降低室上速、房颤、室速和室颤的发生率。两组间差异均有统计学意义(P<0.05),而两组间的不良反应则无差异。结论:AM可以有效减少成人肥厚心肌体外循环术后心律失常发生率且安全高。
Objective To explore the efficacy and safety of amiodarone for prevention of arrhythmias after eardiopulmonary bypass in adult patients with hypertrophic myocardium. Methods 72 patients were randomly assigned to receive intravenous amiodarone of 5 mg/kg 30 min before the opening of aorta, then a continuation of amiodarone of 0.5 mg/min for 72 h （amiodarone group） or saline of the same volume （control group）. The rate of heart spontaneous rebeating and the incidences of various arrhythmias were compared between the two groups. Results In amiodarone group, the incidences of supraventricular, tachycardia, atrial fibrillation, and ventricular fibrillation decreased and the rate of heart spontaneous rebeating increased （P 〈 0.05）. There was no significant difference in adverse reactions between the two groups. Conclusions Amiodarone can effectively reduce the incidences of arrhythmias after cardiopulmonary bypass in dult patients with hypertrophic myocardium and is safe for use,
出处
《实用医学杂志》
CAS
北大核心
2011年第8期1460-1462,共3页
The Journal of Practical Medicine
关键词
心律失常
心性
心肌病
肥厚性
胺碘酮
体外循环
Arrhythmias, cardiac
Cardiomyopathy, hypertrophic
Amiodarone
Cardiopulmonary bypass
