摘要
目的 探讨Ｐ物质（ｓｕｂｓｔａｎｃｅＰ， ＳＰ）与脑血管病的关系。方法 采用放射免疫分析法检测了６０例急性脑梗死患者、４０ 例急性脑出血患者、１５例急性蛛网膜下腔出血患者、１５例血管性痴呆患者和４０ 例对照者血浆及部分患者、对照者脑脊液ＳＰ的含量，同时动态观察血浆ＳＰ水平随病程的变化。结果 脑血管病患者血浆、脑脊液ＳＰ水平均低于对照组，其中急性脑梗死患者及急性蛛网膜下腔出血患者脑脊液中ＳＰ含量下降具统计学意义，余者差异无显著性；急性脑梗死患者第２ 周血浆ＳＰ含量显著高于第１周，第３ 周恢复正常，血浆ＳＰ水平随急性脑出血和急性蛛网膜下腔出血的病程无显著变化。结论 提示ＳＰ参与了脑血管病的发病过程。
Objective\ To investigate the relation between SP and cerebrovascular diseases. Methods\ The levels of substance P(SP) in plasma and cerebrospinal fluid (CSF) were determined by radioimmunoassay thechnique in 40 healthy persons and in the patients with acute cerebral infarction (ACI, \%n\%=60), acute cerebral haemorrhage (ACH, \%n\%=40), acute subarachnoid hemorrhage (SAH, \%n\%=15) and cerebrovascular dementia (CVD, \%n\%=15). The dynamic changes of plasma SP level in the different diseases were also studied. Results\ The investigation showed that the mean SP level of plasma and CSF in patients were lower than that of controls. There were significant changes of SP level in CSF during the course of the ACI group and SAH group. In the ACI group, the mean plasma SP levels returned to normal three weeks after stroke. Conclusion\ The results suggest that SP be involved in the pathogenic process of cerebrovascular diseases.\;
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1999年第6期500-502,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
淮阴市科委社会发展指导性计划项目
关键词
P物质
脑血管病
脑脊液
substance P
cerebrovascular disease
