摘要
目的观察急性等容血液稀释（ANH）对胃癌患者ANH前后外周血免疫细胞因子白细胞介素（IL）-2、IL-6及其mRNA表达的影响。方法择期全麻下行胃癌根治术患者24例,ASAⅠ级或Ⅱ级,随机分为二组：观察组和对照组,每组12例。观察组在全麻诱导后行ANH,对照组未行ANH。分别于麻醉诱导后切皮前（T1）、术后1h（T2）、24h（T3）取静脉血检测细胞因子IL-2和IL-6的血浆浓度及其mRNA表达。结果与T1比较,观察组IL-2、IL-6血浆浓度及mRNA表达于T2~3显著升高（P〈0.05）,对照组于T2显著升高（P〈0.05）。与对照组比较,观察组IL-2、IL-6血浆浓度及mRNA表达于T2~3均明显高于对照组（P〈0.05）。结论急性等容血液稀释自体血回输对机体的IL-2、IL-6等免疫性细胞因子有正向调节作用,能增强机体免疫功能,有利于患者预后。
Objective To investigate the effects of preoperative acute normovolemic hemodilution（ANH） on Interleukin（IL）-2,-6 and expression of their mRNA in patients with gastric cancer.Methods Twenty-four patients with gastric cancer undergoing general anesthesia were randomly divided into two groups（n=12 each）.Patients in group H received ANH,and patients in group C were free from ANH.Blood sample were taken before skin incision（T1）,1h（T2）,24h（T3） after operation for determination of plasma IL-2,IL-6 concentration and expression of their mRNA.Results The level of IL-2,IL-6 as well as their mRNA were higher significantly at T2～3 in group H than those in group C（P0.05）.Conclusion ANH can up-regulate the level of cytokines IL-2 and IL-6 and enhancing immune function of the orgnisms.
出处
《中国煤炭工业医学杂志》
2011年第4期473-475,共3页
Chinese Journal of Coal Industry Medicine
基金
青岛市科技计划项目(项目编号:07-2-1-15-nsh)
