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奥美沙坦酯与左旋氨氯地平合用对高血压蛋白尿的作用 被引量:5

The effect of olmesartan cilextetil combined with levoamlodipine in patients with hypertension and proteinuria
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摘要 目的观察奥美沙坦酯与左旋氨氯地平联合应用对高血压患者蛋白尿的临床疗效。方法将90例高血压合并肾脏损害蛋白尿的患者随机分为A、B两组。A组给予奥美沙坦酯20mg/d和左旋氨氯地平2.5mg/d,B组给予左旋氨氯地平2.5mg/d和氢氯噻嗪12.5mg/d,控制血压及消退蛋白尿,均治疗6个月。观察两组治疗前后血压、24h尿白蛋白总量的变化。结果治疗6个月后,A、B两组血压明显下降(P〈0.01),A组下降[(28.1±1.9)/(32.6±3.9)mmHg]与B组下降[(27.8±3.1)/(31.8±1.7)mmHg]比较差异无统计学意义(P〉0.05)。A、B两组尿蛋白均下降,但A组下降[(0.79±0.09)g/24h]较B组[(0.41±0.13)g/24h]下降更明显,差异有统计学意义(P〈0.01)。结论奥美沙坦酯与左旋氨氯地平合用能较平稳降低血压,显著减少尿蛋白,有效保护肾脏。 Objective To observe the effect of olmesartan cilextetil combined with levoamledipine in patients with hypertension and proteinuria. Methods Ninety patients with hypertension and proteinuria were randomly divided into two groups. Group A of 45 patients received olmesartan cilextetil 20 nag po qd and levoamlodipine 2.5 mg po qd, Group B of 45 patients received levoamlodipine 2.5 mg po qd and hydrochlorthiazide 12.5 mg po qd for 6 months. Blood pressure (BP), 24 h urinary albumin were measured before and after treatment. Re- suits After 6 months, both of two groups can efficiently reduce blood pressure, proteinuria. In contrast, the pro-teinuria in group A was significantly reduced than that of group B after treatment. Conclusion Olmesartan cilextetil combined with levoamlodipine can remarkably decrease BP and proteinuria and better protect renal function.
出处 《中国心血管病研究》 CAS 2011年第4期250-252,共3页 Chinese Journal of Cardiovascular Research
关键词 奥美沙坦酯 左旋氨氯地平 高血压 蛋白尿 Olmesartan cilextetil Levoamlodipine Hypertension Proteinuria
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