摘要
应用比浊法观测了心痛康颗粒剂在体外、体内的抗血小板聚集作用及其对异丙肾上腺素所致心肌缺氧的影响。结果表明：在体外，心痛康颗粒剂能抑制由ＡＤＰ诱导的兔血小板聚集，ＩＣ５０ 为３．０ｍ ｇ／ｍ ｌ；给小鼠连续７ 天灌服心痛康颗粒剂（０．５， １．０， ２．０ｇ／ｋｇ）后，并能显著抑制由ＡＤＰ诱导的血小板聚集作用，且能明显延长实验性心肌缺氧小鼠在缺氧条件下的存活时间。
In vitro experiment, Xin Tong Kang Granules showed marked inhibitory effect on rabbit platelet aggregation induced by ADP. The IC 50 was 3.0mg/ml. In vivo experiment ,Xin Tong Kang Granules also inhibited platelet aggregation by ADP, remarkablely. Besides, Xin Tong Kang Granules promoted the tolerance of experimental mice to hypoxia.
出处
《药学进展》
CAS
1999年第5期303-305,共3页
Progress in Pharmaceutical Sciences
关键词
心痛康颗粒剂
血小板聚集
耐缺氧
中药
Xin Tong Kang Granules Platelet aggregation Normobaric hypoxia test
