摘要
肿瘤细胞对紫杉醇产生耐药是一个多途径过程，除多药耐药外，还与微管蛋白亚型表达的改变、微管相关蛋白的缺失以及微管蛋白聚合力受损等因素有关。本文就近年来这方面的研究进展作一综述。
The acquired resistance of cancer cells to taxol was caused by many factors. Besides multidrug resistance, it was also related with altered tubulin isotype expression, the absense of microtubule associated protein (MAP) and the impaired polymerizing ability of tubulin.This review will provide a overview of recent developments.
出处
《药学进展》
CAS
1999年第5期277-280,共4页
Progress in Pharmaceutical Sciences
