摘要
目的:观察白血病患者骨髓中白血病细胞葡萄糖-6磷酸脱氢酶(G6PD)蛋白的表达情况,探讨G6PD与白血病的关系。方法:应用免疫组化方法检测35例白血病患者和35例非恶性血液病患者骨髓组织标本中白血病细胞G6PD蛋白的表达,比较白血病患者和非恶性血液病患者G6PD蛋白表达率的差异。结果:G6PD蛋白在白血病骨髓组织白血病细胞中呈现弱阳性表达。35例白血病患者骨髓组织中G6PD蛋白阳性表达率为25.7%(9/35),而35例非恶性血液病患者骨髓组织中G6PD蛋白阳性表达率为2.9%(1/35),差异有统计学意义(P<0.05)。结论:白血病可能存在G6PD蛋白的表达上调,值得进一步研究。
Objective：To investigate the expression of G6PD protein in human leukemia and analyze the relationship between G6PD and leukemia.Methods： Immunohistochemical method was applied to detect the expression of G6PD protein in the bone marrow tissue of 35 leukemia patients and 35 cases of non-hematologic malignancies.Non-hematologic malignancies were used as control group.The comparison of G6PD protein rate in leukemia patents and the control was studied.Results： The positive expression rate of G6PD protein was 25.7%（9/35） in leukemia patients and 2.9%（1/35） in control.Data showed a statistically significant difference in G6PD expression between the two groups（P0.05）.Conclusion： G6PD protein was high expressed in leukemia,which needed further study.
出处
《大理学院学报（综合版）》
CAS
2011年第2期27-29,共3页
Journal of Dali University
