摘要
目的 评价并比较氨氯地平（ＡＭ） 和西拉普利（ ＣＩ） 对老年高血压左室肥厚（ ＬＶＨ） 的逆转作用和左室舒张功能的影响。 方法 ５０ 例合并ＬＶＨ 的高血压患者，随机分为ＡＭ 和ＣＩ 治疗组，分别于治疗前及治疗２４周后进行血压测量和超声心动图检查。 结果 ＡＭ 和ＣＩ 治疗后均能显著降低血压（ Ｐ 均＜ ０－０１） ；左室质量指数（ＬＶＭＩ） 均显著下降［ 由（１６４－７ ±３８－２）ｇ·ｍ － ２和（１６３－３ ±３９－２）ｇ·ｍ －２ 分别降至（１３１－０ ±２５－４）ｇ·ｍ －２ 和（１３０－７ ±２６－７）ｇ·ｍ －２，Ｐ 均＜ ０－０１）］ ；左室舒张功能改善（ Ｐ 均＜ ０－０１） ，２ 组间降压幅度、ＬＶＭＩ、Ｅ／ Ａ 变化无显著差异（ Ｐ＞０－０５） 。 结论 ＡＭ 和ＣＩ 每日１ 次给药均可作为治疗高血压伴ＬＶＨ
To investigate the effect of amlodipine (AM) and cilazapril(CI)on left ventricular hypertrophy (LVH) regression and left ventricular diastolic function in elderly essential hypertension(EH)patients. Methods 50 patients with mild and moderate elderly EH accompanied with LVH were divided randomly into AM treatment group( n =25)and CI treatment group ( n =25).The daily dose of AM or CI was 5mg respectively.Both drugs were given once daily.The treatment lasted for 24 weeks.Blood pressure(BP)were measured and echocardiography were examined before and after 24 weeks. Results After treatment,SBP or DBP was significantly reduced both AM and CI group.The left venticular mass indexes(LVMIs)in the two groups were significantly decreased than those before treatment[(164 7±38 2) g·m -2 and(163 3±39 2)g·m -2 vs (131 0±25 4)g·m -2 and(130 7±26 7) g·m -2 , P <0 01,respectively].E/A ratios were increased.No differences were found in the level of BP reduction and the changes of LVMI and E/A ratio between AM and CI. Conclusions Either AM or CI once daily were effective antihypertensive agents in elderly EH with LVH.
出处
《实用老年医学》
CAS
1999年第5期250-251,共2页
Practical Geriatrics
关键词
高血压
左室肥厚
左室舒张功能
西拉普利
Hypertension Left ventricular hypertrophy Left ventricular diastolic function Amlodipine Cilazapril
