摘要
目的：了解前X基因在HBV相关HCC患者中的流行病学分布、前X基因和HBV基因型与HCC的临床关系．方法：患有乙肝的肝细胞肝癌患者（HCC）35例，采用型特异性引物巢式聚合酶链反应进行基因分型．结果：HCC患者35例中B基因型1例，C基因型24例，B／C混合基因型8例，未定型者2例．明确基因型的患者33例，进一步扩增前结论：HCC患者中c基因型、B／C混合基因型较为多见．前X多肽在HCC患者中有较高的编码率，前X区多肽可能和HCC之间有一定相关性．
Objective： To understand the former X gene in HCC patients with HBV-related epidemiological distribution, before the X gene and HBV genotype and clinical HCC. Methods： People with hepatitis B patients with hepatocellular carcinoma （HCC） 35 例 using type-specific primers nested polymerase chain reaction genotyping. Results： HCC in 35 patients with genotype 1 ease B, C genotype of 24 patients, B / C mixed genotype in 8 cases, 2 cases were not finalized. 33 patients with genotype specific, and further amplified before the conclusion： HCC patients with genotype C, B / C mixed genotype is more prevalent, pre X peptides in HCC patients have a higher encoding rate, the former XDistrict peptides may be some correlation between HCC.
关键词
肝炎病毒
乙型基因型前
X基因
癌肝细胞
Hepatitis B virus genotype pre X gene hepatocellular carcinoma
