摘要
目的探讨辛伐他汀对慢性血栓栓塞性肺动脉高压(chronic thromboembolic pulmonary hypertension,CTEPH)患者血浆纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor-1,PAI-1)活性的影响。方法 CTEPH患者分别服用10、20、40mg/天辛伐他汀7、14、21d后,用PAI-1发色底物法检测血浆PAI-1活性。结果与对照组相比,CTEPH组血浆PAI-1水平明显增高;辛伐他汀呈剂量依赖性降低CTEPH患者血浆PAI-1水平。结论辛伐他汀可降低CTEPH患者血浆PAI-1水平。
Objective To investigate the effects of simvastatin to plasminogen activator inhibitor-1（PAI-1） activity in chronic thromboembolic pulmonary hypertension（CTEPH） patients. Methods After 7、14 and 21 days continously use of different dosage of simvastatin,plasma PAI-1 level were dected using chromogenic assay kit. Results Plasma level of PAI-1increase significantly in CTEPH group compared with that in control group;Simvastatin decrease plasma levels of PAI-1 in CTEPH group in a dose dependent manner（P〈0.05）. Conclusions Simvastatin can decrease plasma levels of PAI-1 in CTEPH patients.
出处
《医药论坛杂志》
2011年第2期82-84,共3页
Journal of Medical Forum
