摘要
应用银染PCR-SSCP方法对18例慢性淋巴细胞白血病(CLL)p53、p16基因点突变进行研究,共检出p53基因及p16基因点突变各1例,p53基因突变位于第5外显子突变热点区,p16基因突变位于第2外显子.结果表明CLL存在多种癌基因与抑癌基因改变.
By using silver staining PCR-SSCP method.the mutations of p53 and p!6 genes were detected in 18 patients with chronic lymphocytic leukemia (CLL). One CLL patient demonstrated mutation in exon 5 of p53 gene,another patient showed mutation in exon 2 of p16 gene. These results suggested that CLL has multi-mutations in prooncogenes and oncogenes.
出处
《华中医学杂志》
CAS
1999年第5期195-196,共2页
Central China Medical Journal